Pain perception in acute model mice of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Identifieur interne : 000610 ( Main/Exploration ); précédent : 000609; suivant : 000611Pain perception in acute model mice of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Auteurs : Jihye Park [Corée du Sud] ; Chae-Seok Lim [Corée du Sud] ; Hyunhyo Seo [Corée du Sud] ; Chung-Ah Park [Corée du Sud] ; Min Zhuo [Canada] ; Bong-Kiun Kaang [Corée du Sud] ; Kyungmin Lee [Corée du Sud]Source :
- Molecular Pain [ 1744-8069 ] ; 2015.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (pharmacology), Animals, Astrocytes (drug effects), Corpus Striatum (drug effects), Disease Models, Animal, Dopamine (metabolism), Male, Mice, Mice, Inbred C57BL, Microglia (drug effects), Microglia (metabolism), Motor Activity (drug effects), Neurons (drug effects), Neurons (metabolism), Pain Perception (drug effects), Parkinson Disease.
- MESH :
- chemical , metabolism : Dopamine.
- chemical , pharmacology : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
- drug effects : Astrocytes, Corpus Striatum, Microglia, Motor Activity, Neurons, Pain Perception.
- metabolism : Microglia, Neurons.
- Animals, Disease Models, Animal, Male, Mice, Mice, Inbred C57BL, Parkinson Disease.
Abstract
Pain is the most prominent non-motor symptom observed in patients with Parkinson’s disease (PD). However, the mechanisms underlying the generation of pain in PD have not been well studied. We used a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD to analyze the relationship between pain sensory abnormalities and the degeneration of dopaminergic neurons.
The latency to fall off the rotarod and the total distance traveled in round chamber were significantly reduced in MPTP-induced PD mice, consistent with motor dysfunction. MPTP-treated mice also showed remarkably shorter nociceptive response latencies compared to saline-treated mice and the subcutaneous injection of L-3,4-dihydroxyphenylalanine (L-DOPA) partially reversed pain hypersensitivity induced by MPTP treatment. We found that degeneration of cell bodies and fibers in the substantia nigra pars compacta and the striatum of MPTP-treated mice. In addition, astrocytic and microglial activation was seen in the subthalamic nucleus and neuronal activity was significantly increased in the striatum and globus pallidus. However, we did not observe any changes in neurons, astrocytes, and microglia of both the dorsal and ventral horns in the spinal cord after MPTP treatment.
These results suggest that the dopaminergic nigrostriatal pathway may have a role in inhibiting noxious stimuli, and that abnormal inflammatory responses and neural activity in basal ganglia is correlated to pain processing in PD induced by MPTP treatment.
Url:
DOI: 10.1186/s12990-015-0026-1
PubMed: 25981600
PubMed Central: 4448854
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000266
- to stream Pmc, to step Curation: 000266
- to stream Pmc, to step Checkpoint: 000241
- to stream PubMed, to step Corpus: 000498
- to stream PubMed, to step Curation: 000498
- to stream PubMed, to step Checkpoint: 000498
- to stream Ncbi, to step Merge: 001B66
- to stream Ncbi, to step Curation: 001B66
- to stream Ncbi, to step Checkpoint: 001B66
- to stream Main, to step Merge: 000611
- to stream Main, to step Curation: 000610
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pain perception in acute model mice of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)</title><author><name sortKey="Park, Jihye" sort="Park, Jihye" uniqKey="Park J" first="Jihye" last="Park">Jihye Park</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747 South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Lim, Chae Seok" sort="Lim, Chae Seok" uniqKey="Lim C" first="Chae-Seok" last="Lim">Chae-Seok Lim</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747 South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Seo, Hyunhyo" sort="Seo, Hyunhyo" uniqKey="Seo H" first="Hyunhyo" last="Seo">Hyunhyo Seo</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842 South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Park, Chung Ah" sort="Park, Chung Ah" uniqKey="Park C" first="Chung-Ah" last="Park">Chung-Ah Park</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842 South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Zhuo, Min" sort="Zhuo, Min" uniqKey="Zhuo M" first="Min" last="Zhuo">Min Zhuo</name><affiliation wicri:level="4"><nlm:aff id="Aff3">Department of Physiology, Faculty of Medicine, University of Toronto, The center for the study of pain, 1 King’s College Circle, Toronto, ON M5S 1A8 Canada</nlm:aff><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Kaang, Bong Kiun" sort="Kaang, Bong Kiun" uniqKey="Kaang B" first="Bong-Kiun" last="Kaang">Bong-Kiun Kaang</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747 South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Lee, Kyungmin" sort="Lee, Kyungmin" uniqKey="Lee K" first="Kyungmin" last="Lee">Kyungmin Lee</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842 South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25981600</idno><idno type="pmc">4448854</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448854</idno><idno type="RBID">PMC:4448854</idno><idno type="doi">10.1186/s12990-015-0026-1</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000266</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000266</idno><idno type="wicri:Area/Pmc/Curation">000266</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000266</idno><idno type="wicri:Area/Pmc/Checkpoint">000241</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000241</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000498</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000498</idno><idno type="wicri:Area/PubMed/Curation">000498</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000498</idno><idno type="wicri:Area/PubMed/Checkpoint">000498</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000498</idno><idno type="wicri:Area/Ncbi/Merge">001B66</idno><idno type="wicri:Area/Ncbi/Curation">001B66</idno><idno type="wicri:Area/Ncbi/Checkpoint">001B66</idno><idno type="wicri:Area/Main/Merge">000611</idno><idno type="wicri:Area/Main/Curation">000610</idno><idno type="wicri:Area/Main/Exploration">000610</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Pain perception in acute model mice of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)</title><author><name sortKey="Park, Jihye" sort="Park, Jihye" uniqKey="Park J" first="Jihye" last="Park">Jihye Park</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747 South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Lim, Chae Seok" sort="Lim, Chae Seok" uniqKey="Lim C" first="Chae-Seok" last="Lim">Chae-Seok Lim</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747 South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Seo, Hyunhyo" sort="Seo, Hyunhyo" uniqKey="Seo H" first="Hyunhyo" last="Seo">Hyunhyo Seo</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842 South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Park, Chung Ah" sort="Park, Chung Ah" uniqKey="Park C" first="Chung-Ah" last="Park">Chung-Ah Park</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842 South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Zhuo, Min" sort="Zhuo, Min" uniqKey="Zhuo M" first="Min" last="Zhuo">Min Zhuo</name><affiliation wicri:level="4"><nlm:aff id="Aff3">Department of Physiology, Faculty of Medicine, University of Toronto, The center for the study of pain, 1 King’s College Circle, Toronto, ON M5S 1A8 Canada</nlm:aff><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Kaang, Bong Kiun" sort="Kaang, Bong Kiun" uniqKey="Kaang B" first="Bong-Kiun" last="Kaang">Bong-Kiun Kaang</name><affiliation wicri:level="4"><nlm:aff id="Aff1">Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul, 151-747 South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Neurobiology Laboratory, College of Natural Sciences, Seoul National University, 599 Gwanangno, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><settlement type="city">Séoul</settlement></placeName><orgName type="university">Université nationale de Séoul</orgName></affiliation></author><author><name sortKey="Lee, Kyungmin" sort="Lee, Kyungmin" uniqKey="Lee K" first="Kyungmin" last="Lee">Kyungmin Lee</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu, 700-842 South Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Behavioral Neural Circuitry and Physiology Laboratory, Department of Anatomy, Brain Science & Engineering Institute, Kyungpook National University Graduate School of Medicine, 2-101, Dongin-dong, Jung-gu, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular Pain</title><idno type="eISSN">1744-8069</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (pharmacology)</term><term>Animals</term><term>Astrocytes (drug effects)</term><term>Corpus Striatum (drug effects)</term><term>Disease Models, Animal</term><term>Dopamine (metabolism)</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Microglia (drug effects)</term><term>Microglia (metabolism)</term><term>Motor Activity (drug effects)</term><term>Neurons (drug effects)</term><term>Neurons (metabolism)</term><term>Pain Perception (drug effects)</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Astrocytes</term><term>Corpus Striatum</term><term>Microglia</term><term>Motor Activity</term><term>Neurons</term><term>Pain Perception</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Microglia</term><term>Neurons</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Parkinson Disease</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Pain is the most prominent non-motor symptom observed in patients with Parkinson’s disease (PD). However, the mechanisms underlying the generation of pain in PD have not been well studied. We used a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD to analyze the relationship between pain sensory abnormalities and the degeneration of dopaminergic neurons.</p></sec><sec><title>Results</title><p>The latency to fall off the rotarod and the total distance traveled in round chamber were significantly reduced in MPTP-induced PD mice, consistent with motor dysfunction. MPTP-treated mice also showed remarkably shorter nociceptive response latencies compared to saline-treated mice and the subcutaneous injection of L-3,4-dihydroxyphenylalanine (L-DOPA) partially reversed pain hypersensitivity induced by MPTP treatment. We found that degeneration of cell bodies and fibers in the substantia nigra pars compacta and the striatum of MPTP-treated mice. In addition, astrocytic and microglial activation was seen in the subthalamic nucleus and neuronal activity was significantly increased in the striatum and globus pallidus. However, we did not observe any changes in neurons, astrocytes, and microglia of both the dorsal and ventral horns in the spinal cord after MPTP treatment.</p></sec><sec><title>Conclusions</title><p>These results suggest that the dopaminergic nigrostriatal pathway may have a role in inhibiting noxious stimuli, and that abnormal inflammatory responses and neural activity in basal ganglia is correlated to pain processing in PD induced by MPTP treatment.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chaudhuri, Kr" uniqKey="Chaudhuri K">KR Chaudhuri</name></author><author><name sortKey="Healy, Dg" uniqKey="Healy D">DG Healy</name></author><author><name sortKey="Schapira, Ah" uniqKey="Schapira A">AH Schapira</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Beiske, Ag" uniqKey="Beiske A">AG Beiske</name></author><author><name sortKey="Loge, Jh" uniqKey="Loge J">JH Loge</name></author><author><name sortKey="R Nningen, A" uniqKey="R Nningen A">A Rønningen</name></author><author><name sortKey="Svensson, E" uniqKey="Svensson E">E Svensson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jackson Lewis, V" uniqKey="Jackson Lewis V">V Jackson-Lewis</name></author><author><name sortKey="Przedborski, S" uniqKey="Przedborski S">S Przedborski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Magnusson, Je" uniqKey="Magnusson J">JE Magnusson</name></author><author><name sortKey="Fisher, K" uniqKey="Fisher K">K Fisher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chudler, Eh" uniqKey="Chudler E">EH Chudler</name></author><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosemann, M" uniqKey="Rosemann M">M Rosemann</name></author><author><name sortKey="Ivashkevich, A" uniqKey="Ivashkevich A">A Ivashkevich</name></author><author><name sortKey="Favor, J" uniqKey="Favor J">J Favor</name></author><author><name sortKey="Dalke, C" uniqKey="Dalke C">C Dalke</name></author><author><name sortKey="Holter, Sm" uniqKey="Holter S">SM Hölter</name></author><author><name sortKey="Becker, L" uniqKey="Becker L">L Becker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shimizu, T" uniqKey="Shimizu T">T Shimizu</name></author><author><name sortKey="Iwata, S" uniqKey="Iwata S">S Iwata</name></author><author><name sortKey="Morioka, H" uniqKey="Morioka H">H Morioka</name></author><author><name sortKey="Masuyama, T" uniqKey="Masuyama T">T Masuyama</name></author><author><name sortKey="Fukuda, T" uniqKey="Fukuda T">T Fukuda</name></author><author><name sortKey="Nomoto, M" uniqKey="Nomoto M">M Nomoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jenner, P" uniqKey="Jenner P">P Jenner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krack, P" uniqKey="Krack P">P Krack</name></author><author><name sortKey="Batir, A" uniqKey="Batir A">A Batir</name></author><author><name sortKey="Van Blercom, N" uniqKey="Van Blercom N">N Van Blercom</name></author><author><name sortKey="Chabardes, S" uniqKey="Chabardes S">S Chabardes</name></author><author><name sortKey="Fraix, V" uniqKey="Fraix V">V Fraix</name></author><author><name sortKey="Ardouin, C" uniqKey="Ardouin C">C Ardouin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dellapina, E" uniqKey="Dellapina E">E Dellapina</name></author><author><name sortKey="Ory Magne, F" uniqKey="Ory Magne F">F Ory-Magne</name></author><author><name sortKey="Regragui, W" uniqKey="Regragui W">W Regragui</name></author><author><name sortKey="Thalamas, C" uniqKey="Thalamas C">C Thalamas</name></author><author><name sortKey="Lazorthes, Y" uniqKey="Lazorthes Y">Y Lazorthes</name></author><author><name sortKey="Rascol, O" uniqKey="Rascol O">O Rascol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pellaprat, J" uniqKey="Pellaprat J">J Pellaprat</name></author><author><name sortKey="Ory Magne, F" uniqKey="Ory Magne F">F Ory-Magne</name></author><author><name sortKey="Canivet, C" uniqKey="Canivet C">C Canivet</name></author><author><name sortKey="Simonetta Moreau, M" uniqKey="Simonetta Moreau M">M Simonetta-Moreau</name></author><author><name sortKey="Lotterie, Ja" uniqKey="Lotterie J">JA Lotterie</name></author><author><name sortKey="Radji, F" uniqKey="Radji F">F Radji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stern, Y" uniqKey="Stern Y">Y Stern</name></author><author><name sortKey="Mayeux, R" uniqKey="Mayeux R">R Mayeux</name></author><author><name sortKey="Rosen, J" uniqKey="Rosen J">J Rosen</name></author><author><name sortKey="Ilson, J" uniqKey="Ilson J">J Ilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brooks, Sp" uniqKey="Brooks S">SP Brooks</name></author><author><name sortKey="Dunnett, Sb" uniqKey="Dunnett S">SB Dunnett</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luchtman, Dw" uniqKey="Luchtman D">DW Luchtman</name></author><author><name sortKey="Shao, D" uniqKey="Shao D">D Shao</name></author><author><name sortKey="Song, C" uniqKey="Song C">C Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marchetti, B" uniqKey="Marchetti B">B Marchetti</name></author><author><name sortKey="L Piscopo, F" uniqKey="L Piscopo F">F L’Episcopo</name></author><author><name sortKey="Morale, Mc" uniqKey="Morale M">MC Morale</name></author><author><name sortKey="Tirolo, C" uniqKey="Tirolo C">C Tirolo</name></author><author><name sortKey="Testa, N" uniqKey="Testa N">N Testa</name></author><author><name sortKey="Caniglia, S" uniqKey="Caniglia S">S Caniglia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halliday, Gm" uniqKey="Halliday G">GM Halliday</name></author><author><name sortKey="Stevens, Ch" uniqKey="Stevens C">CH Stevens</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Henning, J" uniqKey="Henning J">J Henning</name></author><author><name sortKey="Strauss, U" uniqKey="Strauss U">U Strauss</name></author><author><name sortKey="Wree, A" uniqKey="Wree A">A Wree</name></author><author><name sortKey="Gimsa, J" uniqKey="Gimsa J">J Gimsa</name></author><author><name sortKey="Rolfs, A" uniqKey="Rolfs A">A Rolfs</name></author><author><name sortKey="Benecke, R" uniqKey="Benecke R">R Benecke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamby, Me" uniqKey="Hamby M">ME Hamby</name></author><author><name sortKey="Sofroniew, Mv" uniqKey="Sofroniew M">MV Sofroniew</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langston, Jw" uniqKey="Langston J">JW Langston</name></author><author><name sortKey="Forno, Ls" uniqKey="Forno L">LS Forno</name></author><author><name sortKey="Tetrud, J" uniqKey="Tetrud J">J Tetrud</name></author><author><name sortKey="Reeves, Ag" uniqKey="Reeves A">AG Reeves</name></author><author><name sortKey="Kaplan, Ja" uniqKey="Kaplan J">JA Kaplan</name></author><author><name sortKey="Karluk, D" uniqKey="Karluk D">D Karluk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Niranjan, R" uniqKey="Niranjan R">R Niranjan</name></author><author><name sortKey="Nath, C" uniqKey="Nath C">C Nath</name></author><author><name sortKey="Shukla, R" uniqKey="Shukla R">R Shukla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petroske, E" uniqKey="Petroske E">E Petroske</name></author><author><name sortKey="Meredith, G" uniqKey="Meredith G">G Meredith</name></author><author><name sortKey="Callen, S" uniqKey="Callen S">S Callen</name></author><author><name sortKey="Totterdell, S" uniqKey="Totterdell S">S Totterdell</name></author><author><name sortKey="Lau, Y S" uniqKey="Lau Y">Y-S Lau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sedelis, M" uniqKey="Sedelis M">M Sedelis</name></author><author><name sortKey="Schwarting, Rk" uniqKey="Schwarting R">RK Schwarting</name></author><author><name sortKey="Huston, Jp" uniqKey="Huston J">JP Huston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vivacqua, G" uniqKey="Vivacqua G">G Vivacqua</name></author><author><name sortKey="Biagioni, F" uniqKey="Biagioni F">F Biagioni</name></author><author><name sortKey="Yu, S" uniqKey="Yu S">S Yu</name></author><author><name sortKey="Casini, A" uniqKey="Casini A">A Casini</name></author><author><name sortKey="Bucci, D" uniqKey="Bucci D">D Bucci</name></author><author><name sortKey="D Ste, L" uniqKey="D Ste L">L D’Este</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tagliati, M" uniqKey="Tagliati M">M Tagliati</name></author><author><name sortKey="Martin, C" uniqKey="Martin C">C Martin</name></author><author><name sortKey="Alterman, R" uniqKey="Alterman R">R Alterman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pani, L" uniqKey="Pani L">L Pani</name></author><author><name sortKey="Porcella, A" uniqKey="Porcella A">A Porcella</name></author><author><name sortKey="Gessa, G" uniqKey="Gessa G">G Gessa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teicher, Mh" uniqKey="Teicher M">MH Teicher</name></author><author><name sortKey="Anderson, Cm" uniqKey="Anderson C">CM Anderson</name></author><author><name sortKey="Polcari, A" uniqKey="Polcari A">A Polcari</name></author><author><name sortKey="Glod, Ca" uniqKey="Glod C">CA Glod</name></author><author><name sortKey="Maas, Lc" uniqKey="Maas L">LC Maas</name></author><author><name sortKey="Renshaw, Pf" uniqKey="Renshaw P">PF Renshaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nieoullon, A" uniqKey="Nieoullon A">A Nieoullon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chudler, Eh" uniqKey="Chudler E">EH Chudler</name></author><author><name sortKey="Dong, Wk" uniqKey="Dong W">WK Dong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chesselet, M F" uniqKey="Chesselet M">M-F Chesselet</name></author><author><name sortKey="Delfs, Jm" uniqKey="Delfs J">JM Delfs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hagelberg, N" uniqKey="Hagelberg N">N Hagelberg</name></author><author><name sortKey="J Skel Inen, Sk" uniqKey="J Skel Inen S">SK Jääskeläinen</name></author><author><name sortKey="Martikainen, Ik" uniqKey="Martikainen I">IK Martikainen</name></author><author><name sortKey="Mansikka, H" uniqKey="Mansikka H">H Mansikka</name></author><author><name sortKey="Forssell, H" uniqKey="Forssell H">H Forssell</name></author><author><name sortKey="Scheinin, H" uniqKey="Scheinin H">H Scheinin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levant, B" uniqKey="Levant B">B Levant</name></author><author><name sortKey="Mccarson, Ke" uniqKey="Mccarson K">KE McCarson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, K" uniqKey="Gao K">K Gao</name></author><author><name sortKey="Mason, P" uniqKey="Mason P">P Mason</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heikkila, Re" uniqKey="Heikkila R">RE Heikkila</name></author><author><name sortKey="Sieber, B A" uniqKey="Sieber B">B-A Sieber</name></author><author><name sortKey="Manzino, L" uniqKey="Manzino L">L Manzino</name></author><author><name sortKey="Sonsalla, Pk" uniqKey="Sonsalla P">PK Sonsalla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosland, Jh" uniqKey="Rosland J">JH Rosland</name></author><author><name sortKey="Hunskaar, S" uniqKey="Hunskaar S">S Hunskaar</name></author><author><name sortKey="Broch, Oj" uniqKey="Broch O">OJ Broch</name></author><author><name sortKey="Hole, K" uniqKey="Hole K">K Hole</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Orega Legaspi, Jm" uniqKey="Orega Legaspi J">JM Orega-Legaspi</name></author><author><name sortKey="De Gortari, P" uniqKey="De Gortari P">P de Gortari</name></author><author><name sortKey="Gardu O Gutierrez, R" uniqKey="Gardu O Gutierrez R">R Garduño-Gutiérrez</name></author><author><name sortKey="Amaya, Mi" uniqKey="Amaya M">MI Amaya</name></author><author><name sortKey="Le N Olea, M" uniqKey="Le N Olea M">M León-Olea</name></author><author><name sortKey="Coffeen, U" uniqKey="Coffeen U">U Coffeen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coffeen, U" uniqKey="Coffeen U">U Coffeen</name></author><author><name sortKey="Ortega Legaspi, Jm" uniqKey="Ortega Legaspi J">JM Ortega-Legaspi</name></author><author><name sortKey="De Gortari, P" uniqKey="De Gortari P">P de Gortari</name></author><author><name sortKey="Sim N Arceo, K" uniqKey="Sim N Arceo K">K Simón-Arceo</name></author><author><name sortKey="Jaimes, O" uniqKey="Jaimes O">O Jaimes</name></author><author><name sortKey="Amaya, Mi" uniqKey="Amaya M">MI Amaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bourgoin, S" uniqKey="Bourgoin S">S Bourgoin</name></author><author><name sortKey="Pohl, M" uniqKey="Pohl M">M Pohl</name></author><author><name sortKey="Mauborgne, A" uniqKey="Mauborgne A">A Mauborgne</name></author><author><name sortKey="Benoliel, Jj" uniqKey="Benoliel J">JJ Benoliel</name></author><author><name sortKey="Collin, E" uniqKey="Collin E">E Collin</name></author><author><name sortKey="Hamon, M" uniqKey="Hamon M">M Hamon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wiesenfeld Hallin, Z" uniqKey="Wiesenfeld Hallin Z">Z Wiesenfeld-Hallin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rozas, G" uniqKey="Rozas G">G Rozas</name></author><author><name sortKey="L Pez Mart N, E" uniqKey="L Pez Mart N E">E López-Martın</name></author><author><name sortKey="Guerra, M" uniqKey="Guerra M">M Guerra</name></author><author><name sortKey="Labandeira Garc A, J" uniqKey="Labandeira Garc A J">J Labandeira-Garcıa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, H" uniqKey="Jiang H">H Jiang</name></author><author><name sortKey="Fang, D" uniqKey="Fang D">D Fang</name></author><author><name sortKey="Kong, Ly" uniqKey="Kong L">LY Kong</name></author><author><name sortKey="Jin, Zr" uniqKey="Jin Z">ZR Jin</name></author><author><name sortKey="Cai, J" uniqKey="Cai J">J Cai</name></author><author><name sortKey="Kang, Xj" uniqKey="Kang X">XJ Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Mm" uniqKey="Zhang M">MM Zhang</name></author><author><name sortKey="Liu, Sb" uniqKey="Liu S">SB Liu</name></author><author><name sortKey="Chen, T" uniqKey="Chen T">T Chen</name></author><author><name sortKey="Koga, K" uniqKey="Koga K">K Koga</name></author><author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name></author><author><name sortKey="Li, Yq" uniqKey="Li Y">YQ Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, T" uniqKey="Chen T">T Chen</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Dong, Yl" uniqKey="Dong Y">YL Dong</name></author><author><name sortKey="Zhang, Mm" uniqKey="Zhang M">MM Zhang</name></author><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name></author><author><name sortKey="Koga, K" uniqKey="Koga K">K Koga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Mg" uniqKey="Liu M">MG Liu</name></author><author><name sortKey="Zhuo, M" uniqKey="Zhuo M">M Zhuo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yu, D" uniqKey="Yu D">D Yu</name></author><author><name sortKey="Thakor, Dk" uniqKey="Thakor D">DK Thakor</name></author><author><name sortKey="Han, I" uniqKey="Han I">I Han</name></author><author><name sortKey="Ropper, Ae" uniqKey="Ropper A">AE Ropper</name></author><author><name sortKey="Haragopal, H" uniqKey="Haragopal H">H Haragopal</name></author><author><name sortKey="Sidman, Rl" uniqKey="Sidman R">RL Sidman</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>Corée du Sud</li></country><region><li>Ontario</li></region><settlement><li>Séoul</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li><li>Université nationale de Séoul</li></orgName></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Park, Jihye" sort="Park, Jihye" uniqKey="Park J" first="Jihye" last="Park">Jihye Park</name></noRegion><name sortKey="Kaang, Bong Kiun" sort="Kaang, Bong Kiun" uniqKey="Kaang B" first="Bong-Kiun" last="Kaang">Bong-Kiun Kaang</name><name sortKey="Lee, Kyungmin" sort="Lee, Kyungmin" uniqKey="Lee K" first="Kyungmin" last="Lee">Kyungmin Lee</name><name sortKey="Lim, Chae Seok" sort="Lim, Chae Seok" uniqKey="Lim C" first="Chae-Seok" last="Lim">Chae-Seok Lim</name><name sortKey="Park, Chung Ah" sort="Park, Chung Ah" uniqKey="Park C" first="Chung-Ah" last="Park">Chung-Ah Park</name><name sortKey="Seo, Hyunhyo" sort="Seo, Hyunhyo" uniqKey="Seo H" first="Hyunhyo" last="Seo">Hyunhyo Seo</name></country><country name="Canada"><region name="Ontario"><name sortKey="Zhuo, Min" sort="Zhuo, Min" uniqKey="Zhuo M" first="Min" last="Zhuo">Min Zhuo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000610 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000610 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4448854
|texte= Pain perception in acute model mice of Parkinson’s disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25981600" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |